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常见毒性标准(CTC)1999英文版VIP专享VIP免费

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CTC Version 2.0Publish Date: April 30, 1999Cancer Therapy Evaluation Program1Revised March 23, 1998Common Toxicity Criteria, Version 2.0DCTD, NCI, NIH, DHHS March 1998COMMON TOXICITY CRITERIA (CTC)GradeAdverse Event01234ALLERGY/IMMUNOLOGYAllergic reaction/hypersensitivity(including drug fever)nonetransient rash, drugfever <38°C (<100.4°F)urticaria, drug fever≥38°C (≥100.4°F),and/or asymptomaticbronchospasmsymptomaticbronchospasm,requiring parenteralmedication(s), with orwithout urticaria;allergy-relatededema/angioedemaanaphylaxisNote: Isolated urticaria, in the absence of other manifestations of an allergic or hypersensitivity reaction, is graded in the DERMATOLOGY/SKIN category.Allergic rhinitis(including sneezing, nasalstuffiness, postnasal drip)nonemild, not requiringtreatmentmoderate, requiringtreatment--Autoimmune reactionnoneserologic or otherevidence ofautoimmune reactionbut patient isasymptomatic (e.g.,vitiligo), all organfunction is normal andno treatment is requiredevidence ofautoimmune reactioninvolving a non-essential organ orfunction (e.g.,hypothyroidism),requiring treatmentother thanimmunosuppressivedrugsreversible autoimmunereaction involvingfunction of a majororgan or other adverseevent (e.g., transientcolitis or anemia),requiring short-termimmunosuppressivetreatmentautoimmune reactioncausing major grade 4organ dysfunction;progressive andirreversible reaction;long-termadministration of high-dose immuno-suppressive therapyrequiredAlso consider Hypothyroidism, Colitis, Hemoglobin, Hemolysis.Serum sicknessnone--present-Urticaria is graded in the DERMATOLOGY/SKIN category if it occurs as an isolated symptom. If it occurs with other manifestations of allergic orhypersensitivity reaction, grade as Allergic reaction/hypersensitivity above.Vasculitisnonemild, not requiringtreatmentsymptomatic, requ...

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