生理学报ActaPhysiologicaSinica,June25,2005,57(3):389-394http://www.actaps.com.cn389研究论文Received2004-03-23Accepted2005-04-20ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina(No.C030313),theMinistryofScienceandTechnologyofChina(KNAW01CDP019)andRoyalAcademyofScienceofNetherlands.*Correspondingauthor.Tel:+86-551-2922342;Fax:+86-551-5120742;E-mail:anhuigi@mail.hf.ah.cn月经周期对女性睡眠-觉醒和静息-活动的影响刘红艳1，包爱民2，周江宁2，刘荣玉1,*1安徽医科大学第一附属医院老年呼吸内科，合肥230022;2中国科学技术大学生命科学院神经生物学系，合肥230027摘要：目前有关月经周期对睡眠影响的研究结果并不一致，而对月经周期中昼夜睡眠-觉醒及静息-活动节律尚缺乏系统性的研究。本研究旨在观察正常育龄期女性月经周期中睡眠-觉醒及静息-活动昼夜节律的变化。我们采用静息-活动监测仪(actigraphy)和睡眠日志，调查了12个自然生活状态下健康育龄期妇女在月经周期不同阶段，即行经期、围排卵期、黄体早期及黄体晚期中睡眠与活动节律的变化。结果显示，睡眠-觉醒节律参数在四期之间无统计学显著差异；而静息-活动节律方面，所有受试女性静息-活动节律的平均日周期长度为(24.01±0.29)h，并且四期之间无显著性差异。行经期日间稳定系数(interdailystability,IS)比黄体早期显著增加(P<0.05)。黄体早期日间活动开始时间明显较黄体晚期提前(P<0.05);黄体早期的活动峰值时相比围排卵期显著提前(P<0.05)。月经周期可以影响静息-活动昼夜节律时相。而总体静息-活动数量与质量未发生显著变化；健康育龄期妇女在月经周期的各阶段中睡眠-觉醒节律亦无明显变异。关键词：昼夜节律；月经周期；静息-活动；睡眠；监测仪中图分类号：Q492.5;R338.63;R339.2+2Changesincircadiansleep-wakeandrest-activityrhythmsduringdifferentphasesofmenstrualcycleLIUHong-Yan1,BAOAi-Min2,ZHOUJiang-Ning2,LIURong-Yu1,*1LungDepartmentofGeriatricsInstitute,TheFirstAffiliatedHospitalofAnhuiMedicalUniversity,Hefei230022,China;2Depart-mentofNeurobiology,SchoolofLifeScience,UniversityofScienceandTechnologyofChina,Hefei230027,ChinaAbstract:Theresultsofpreviousstudiesonthemenstrual-relatedsleepchangeswereinconsistent.Themenstrual-relatedcircadiansleep-wakeandrest-activityrhythmschangesarestilluncertain.Usingactigraphicmonitoringofwristactivity,weinvestigatedthesleep-wakeandrest-activitypatternsof12normallycyclichealthywomenduringreproductivelife.Multivariateanalyseswereperformedduringthefourphasesofthemenstrualcycle:menstrualphase(lstto5thdayofmenstrualcycle),latefollicular/peri-ovulationphase(11thto15thday),earlytomidlutealphase(18thto23thday)andlatelutealphase(25thto28thday),respectively.Thevariablesofcircadiansleep-wakepatternweresimilarinthefourphases,exceptanincreasedtendencyofthesleeplatencyinperi-ovulationphasecomparedwiththeearlytomid-lutealphase(19±18vs9±6),butunfortunatelynostatisticalsignificancewerefound(P<0.10).Concerningthecircadianpatterningofrestandactivity,theinterdailystability(IS)inmenstrualphasewassignificantlyhigherthantheearlytomidlutealphase(P<0.05).Inearlytomidlutealphase,theM10onsettimewassignificantlyearliercomparedwiththatofthelatefollicular/peri-ovulationphase(P<0.05),andthecosinorpeaktimewassignificantlyearliercomparedwiththatofthelatelutealphase(P<0.05).Thecircadianperiodogramcalculatedtheperiodlengthoftherhythmofaveragewoman.Theaveragelengthwas(24.01±0.29)h,andtherewasnosignificantdifferenceamongthefourmenstrualphases.Theresultssuggestthatthephaseofcircadianrest-activityrhythmmaybemodulatedbythemenstrualcycle,butthequantityandqualityoftherest-activityrhythmhavenoessentiald...
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