写缸用疼痛学杂志2010年6月第6蒙在第3翻Poinαin1.1un.,2010.VoL6.Nα3吗啡经蛛网膜下腔植入式输注系统治疗晚期癌痛的临床观察邹睡何云武it石银4鲁吉萨君it茸李成E摘要E目的观察经蛛网膜下腔植入式输注系统输注吗啡在晚期癌痛患者镇痛的疗效.方法晚期痛痛住院患者25例，通过蛛网膜下腔植入式输注系统输注吗啡镇痛，观察治疗前与吗啡输注后2'"、72h，1周、1月的VAS评分、睡眠质量(Q:田、毒副反应.结果1月后疼痛控制程度达优者22例(88%)，良1例(4%)，一般l例(4%)，差1例问%);优良率为92%.睡眠质量优22例(88%)，良3例(12%λ毒副反应有皮肤瘟痒2例(8%)，恶心3例02%)，便秘3例02%)，尿满留4例(16%)，未见嗜睡和降吸抑制者.结论经蛛网膜下脏植入式输注系统输注吗啡对晚期痛痛患者的镇痛疗效确切，不良反应少.E关键词E蛛网膝下腔s吗啡s输注泵，植入型:肿瘤s疼痛s镇痛Iofusiooofmorpbil赔bysublll1lChnoidspaceimplantablepumpiotbe缸四......‘orpatiE皿tswitbad叫"血paiOZOUCong,Hf';Yun--wu..LONGShi-yin.etal.PainDepartment0/山&condAffilÙJ.t(!dHos庐山l.University0/SouthChina.H(!ngya吨，Hunan4.21001.China[Abstract)ObjectiveToobservetheeffiCllcyofsulmrachnoidspaceimplantablemorphinepumpinpatientswithadvancedCIIncerpai比Met画。也Twenty-fivepati创ltSwithadvancedCIIncerpainwetettt:'dtt:dby∞ntinuousinfusionofmorphinewithsubatachnoidspaceimplantablemotphinepump.TheanalgesiceffiCllcyWlISevaluatedwithvisualanalogues值le，sleepingqualityandsidereactionsatpre-treatmentand24,72h,7daysandonemonthafter由etreatment.RωultsAfteramonth,theefficacyof22cases(88%)wi甜excdlent.lcase(4.%)g∞d.1case(4.%)effectiveand1case(4.%)归。t.Theexcdl凹tandgoodr-dteswett:92%.Excdlentqualityofsleepw田in22cases(88灿，goodWlISin3cases02%).Thesidereactionsincludeds凶1itch吨in2也晒(8灿.="剧in3CIIses(12灿，∞m庐山in3CIISω02灿nrina巧retentionin4caSe806灿，nolemargyandtespir-dtOty(叩'"副on.Condusi回Withlessside-tt:'dctions,thedf民tofsubar-dchnoidimplantedmorphinepumpinthettt:'dtm凹tofpatientswithadvancedcanct:tpainisddinit，ι[Keywm巾JS"h.
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