DOI∶10.13192/j.issn.1000-1719.2014.10.004电针结合推拿对气滞血瘀型原发性痛经患者血清PGF2α及β-EP含量的影响周琨,李新建(北京体育大学医院,北京100084)摘要:目的:通过观察、比较电针结合推拿与痛经灵颗粒两种不同治疗方法对气滞血瘀型原发性痛经的临床疗效及对血清前列腺素(PGF2α)、β‐内啡肽(β-EP)的影响,寻求一种更好治疗该病的方法。方法:将60例气滞血瘀型原发性痛经患者随机分成治疗组和对照组,每组30例。治疗组采取电针结合推拿的治疗方法,对照组采取口服痛经灵颗粒的治疗方法。观察两组临床疗效和治疗前后血清PGF2α、β-EP水平的变化。结果:(1)治疗前与治疗后3个月经周期内,两组的VAS评分均呈下降趋势,但两组组间比较,治疗组变化比对照组显著,差异有统计学意义(P<0.05)。(2)治疗前,两组血清中PGF2α及β-EP含量与正常对照组比较显示,血清的PGF2α水平均显著升高,β-EP水平均显著降低(P<0.05)。治疗后,两组血清中PGF2α水平均显著降低,β-EP水平均显著升高(P<0.05)。组间比较:差异不明显,无统计学意义(P>0.05)。(3)两组的临床疗效比较:治疗组总有效率为90%,对照组为80%,两组相比治疗组显著高于对照组,差异有统计学意义(P<0.05)。结论:(1)电针结合推拿和痛经灵颗粒对血清中PGF2α及β-EP含量均有调整作用,但二者作用差异不明显。(2)两种治疗方法对气滞血瘀型原发型痛经均有治疗作用,但二者相比,电针结合推拿的治疗方法略优于痛经灵颗粒。关键词:原发性痛经;气滞血瘀型;电针;推拿;痛经灵;PGF2α;β-EP中图分类号:R271.113文献标志码:A文章编号:1000-1719(2014)10-2041-03EffectofElectroacupunctureandMassageonPrimaryDysmenorrhealofQiStagnationandBloodStasisTypeinPatientsZHOUKun,LIXinjian(BeijingSportUniversity,Beijing100084,China)Abstract:Objective:ToobservethevarietyofPGF2αandβ-EPandcomparethetherapeuticeffectofTongjinglingranulesandcombinationtherapyofelectroacupunctureandmassageonprimarydysmenorrhealofQistagnationandbloodstasistypeinpatientsataspecifiedtimeandtofindoutabetterwaywhichcanmakethecurativeeffectlastlonger.Methods:Werandomlydi-vided60patientsintotreatmentgroup(30cases)andcontrolgroup(30cases).Patientsintreatmentgroupreceivedthecombina-tiontherapyofelectroacupunctureandmassage,whilepatientsincontrolgroupreceivedTongjingling.Weusedvisualanalogscale(VAS),PGF2αandβ-EPandthetotaleffectiveratetoassesscurativeeffect.Wecomparedtheoveralloutcomeinbothgroupsbeforeandat1,2,and3menstrualcyclesaftertreatmenttofindoutawaywhichcanmakethecurativeeffectlastlonger.Results:Followingtreatment,weobtainedthefollowingresultsintreatmentgroupandcontrolgroup:(1)VASscoreoftwogroupsfallin3menstrualcyclesaftertreatmentbutthevarietyoftreatmentgroupwasmoreobviousthanthatofcontrolgroup(P<0.05).(2)TwogroupscanmakethelevelsofPGF2αandβ-EPvariedbuttherewasnodifferencewithttest(P>0.05)betweenthetwogroups,indicatingtheirincomparability.(3)Thetotaleffectiveratewas90.0%intreatmentgroupand80%incontrolgroup.Conclusion:(1)TwogroupscanmakethelevelsofPGF2αandβ-EPvariedbuttherewasnodifferencebetweenthetwogroups.(2)Electroacupunctureandmassagecangetbettercurativeeffect.Keywords:primarydysmenorrhea;qistagnationandbloodstasissyndrome;electroacupuncture;massage;Tongjinglingran-ules;PGF2α;β-EP收稿日期:2014-04-21基金项目:2012年北京体育大学自主课题(2012YB016)作者简介:周琨(1963-),女,江苏盐城人,副主任医师,学士,研究方向:妇科常见疾病的治疗。通讯作者:李新建(1979-),男,河北赵县人,副主任医师,博士,研究方向:中医骨伤学。原发性痛经即功能性痛经,是指月经期腹部疼痛,常呈痉挛性,多集中在下腹部,不伴有明显的盆腔器质性疾病,其症状包括腹...