肠溶包衣材料在药物制剂中的应用摘要：口服给药是最常用的临床给药方法。但是，由于胃中含有各种消化酶，口腔中容易摄入消化酶耐受性差的胰岛素，降钙素，新开发的人生长激素，促红细胞生成素等口服肽。胃中的消化酶破坏不能达到预期的治疗目的。在临床实践中，只能通过注射给药。对于需要长期服药的患者来说，这是非常不舒服的，许多高分子多肽药物即使在注射后也不容易被人体吸收。另外，由于生活习惯的变化，溃疡性大肠的治疗不断增加，如果使用通常的口服给药方法，则药物在到达给药部位之前不会被吸收到体内，局部治疗不能有效地执行。药物的某些特殊性质和医疗需求促进了肠溶包衣材料的开发和应用。通过在胃（pH1-3.5），小肠（pH5-7）和大肠（pH8.3-8.4）中使用不同的pH值，可以制备在不同pH条件下溶解的聚合物材料。关键词：肠溶包衣；药物制剂；应用Abstract:Oraladministrationisthemostcommonlyusedmethodofclinicaladministration.However,sincethestomachcontainsvariousdigestiveenzymes,oralpeptidessuchasinsulin,calcitonin,andnewlydevelopedhumangrowthhormoneanderythropoietinwhicharepoorlytoleratedbydigestiveenzymesareeasilytakenbytheoralcavity.Digestiveenzymedestructioninthestomachdoesnotachievethedesiredtherapeuticpurpose.Inclinicalpractice,itcanonlybeadministeredbyinjection.Itisextremelyuncomfortableforthosewhoneedlong-termmedication,andmanymacromolecularpeptidedrugsarenoteasilyabsorbedbythebodyevenafterinjection.Inaddition,inthetreatmentofulcerativelargeintestinethatisconstantlyincreasingduetochangesinlifestyle,iftheusualoraladministrationmethodisused,thedrugisnotabsorbedintothebodyuntilitreachesthesiteofadministration,andlocaltreatmentcannotbeeffectivelyperformed.Certainspecialpropertiesofdrugsandmedicalneedspromotethedevelopmentandapplicationofentericcoatedmaterials.ByusingdifferentpHvaluesinstomach(pH1-3.5),smallintestine(pH5-7),andlargeintestine(pH8.3-8.4),polymermaterialsthatdissolveunderdifferentpHconditionscanbeprepared.Keywords:entericcoating;pharmaceuticalpreparation;application目录一、前言........................................................................................................................1二、肠溶包衣材料的种类概述....................................................................................2（一）天然高分子胶类.........................................................................................2（二）纤维素及其衍生物类.................................................................................3（三）丙烯酸树脂(AcrylicResin)........................................................................3（四）前药型大肠靶向DDS...............................................................................3（五）大肠内崩解性药用高分子包衣材料.........................................................41.偶氮连接聚合体HEMA-St-DVAB..............................................................42.氨基甲酸乙酯高分子聚合物.......................................................................5（六）聚乙烯醇醋酸苯二甲酸酯.......................................................................5三、肠溶包衣材料发展历程及应用............................................................................5（一）虫胶(shellac)...............................................................................................6（二）聚乙烯醇乙酸苯二甲酸酯(PVAP).............................................................6（三）丙烯酸树脂类(polyacrylicresin)................................................................7...
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