目录摘要...........................................................................................................1Abstract.....................................................................................................2第一章前言..............................................................................................41.1生物材料表面诱导的血栓形成...................................................41.1.1材料表面诱发血栓..............................................................41.1.2纤溶过程..............................................................................41.2表面改性策略...............................................................................51.2.1生物惰性表面......................................................................51.2.2生物活性表面......................................................................61.2.3促内皮化表面......................................................................71.2.4血栓应激性抗血栓策略......................................................81.3课题提出.......................................................................................91.3.1研究目的及意义..................................................................91.3.2研究内容及方案................................................................10第二章实验部分....................................................................................112.1实验材料.....................................................................................112.1.1试剂与药品........................................................................112.1.2实验设备............................................................................122.2实验过程.....................................................................................122.2.1肝素-聚赖氨酸纳米颗粒的制备与表征...........................122.2.2硅片表面涂覆多巴胺........................................................132.2.3表面负载两种纳米颗粒...................................................142.2.4混合纳米颗粒改性表面的表征........................................142.2.5硅改性表面的溶栓测试...................................................152.2.6改性表面内皮细胞增殖与黏附实验................................15第三章结论与分析................................................................................163.1肝素-聚赖氨酸纳米颗粒（HPs）的制备及两种纳米颗粒的粒径测试...............................................................................................163.2纳米颗粒改性表面的表征.........................................................163.2.1纳米颗粒改性表面浸润性................................................163.2.2凝血时间测试....................................................................173.3凝血酶响应性酶活性测试.........................................................183.4材料表面内皮化实验.................................................................19结论.........................................................................................................21参考文献.................................................................................................22致谢.........................................................................................................24摘要血液接触材料，在临床医学和生物技术领域已经得到了广泛的应用，如冠状动脉支架，心脏瓣膜，血液透析器，心肺...
