ALDH-2 与酒精依赖性的相关性研究进展摘 要：ALDH-2 酶与酒精代谢有着密切联系，不同人群的 ALDH-2 基因型频率不同催化体内乙醛氧化为乙酸能力的程度也会不同。研究 ALDH-2 基因与酒精之间的依赖性关系，能够帮助治疗一些酗酒后易患的疾病。比如：携带ALDH-2 等位基因的个体在饮酒后体内产生的乙醛代谢受到困难，乙醛在血液内浓度升高，就会导致体内组织器官受损。近年来，关于 ALDH-2 基因缺陷与相关病症的关系的研究日益增多。ALDH-2 在一些疾病的预防和治疗中将会有很大的应用前景。现就 ALDH-2 与人类疾病之间的相互关系作一综述。关键词：ALDH-2；ADH；酒精；疾病；肿瘤Research progress on the correlation between ALDH-2 and alcohol dependence[Abstract] ALDH-2 enzyme is closely related to alcohol metabolism, and the catalytic capacity of acetaldehyde oxidation to acetic acid in different populations varies with different ALDH-2 genotypes and frequencies. Studying the relationship between the ALDH-2 gene and alcohol dependence could help treat some diseases that are associated with alcoholism. For example, individuals with the ALDH-2 allele have difficulty metabolizing acetaldehyde, which is produced in the blood and can lead to tissue and organ damage. In recent years, more and more studies have been conducted on the relationship between ALDH-2 gene defects and related diseases. ALDH-2 will have great prospects in the prevention and treatment of some diseases. The relationship between ALDH-2 and human diseases is reviewed.[Key words] ALDH-2;ADH;Alcohol;Disease;Thetumor一、ALDH-2 与饮酒的关系。人体内的 ALDH-2 等位基因与人体内酒精的代谢以及个体饮酒后对自身行为的控制和影响都有着密切的关系。说到饮酒，那么为什么有的人在饮酒时千杯不醉，有的人一杯下肚儿脸颊就像猴儿屁股一样呢？这与人体内的酒精代谢酶 ADH 酶和 ALDH-2 酶的作用有关了。一般情况下，个体在饮酒后，体内的酒精进行分解和代谢的过程有两个阶段（如），体内的酒精首先在乙醇脱氢酶（ADH）的作用下脱氢成对人体有害的乙醛，然...
