2型糖尿病患者胰岛素样生长因子-1及颈动脉内膜中层厚度与大血管并发症的关系

2 型糖尿病患者胰岛素样生长因子-1 与颈动脉膜中层厚度与大血管并发症的关系（余晓慧 市第一人民医院）摘要：目的 分析血清胰岛素样生长因子-1（IGF-1）水平、颈动脉膜中层厚度在 2 型糖尿病合并大血管并发症患者的变化与临床意义。方法 正常对比组 20 例，2 型糖尿病无合并症组 20 例，2 型糖尿病合并大血管并发症组 20 例，分别测定各组血清 IGF-1 水平、颈动脉中层厚度。结果 2 型糖尿病无合并症组 IGF-1 水平与对比组相比明显降低，差别有统计学意义（P<0.05）；2 型糖尿病合并大血管并发症组 IGF-1 较 2 型糖尿病无合并症组降低，差别有统计学意义（P<0.05）；2 型糖尿病合并大血管并发症组患者颈动脉膜中层厚度比对比组、2 型糖尿病无合并症组明显增加，差别有统计学意义（P<0.05）。结论 IGF-1 与颈动脉膜中层厚度与 2 型糖尿病大血管病变有显著相关性，是敏感的预警指标。关键词：2 型糖尿病；糖尿病大血管病变；胰岛素样生长因子-1；颈动脉膜中层厚度；The relationship ofInsulin-like growth Factor-1 and carotid intima-media thickness with Macrovascular complications in type 2 Diabetic patients[Abstract] Objective To investigate the relationship of insulin-like growth factor-1(IGF-1)and carotid intima-media thickness(CIMT) with Macrovascular complications in type 2 Diabetic patients.Methods: The serum IGF-1 and CIMT was detected in 20 of healthy controls,20 of type 2 diabetes without complications and 20 of type 2 diabetic macroangiopathy patients.ResultsThe serum IGF-1in type 2 diabetes was lower than that in healthy controls(P< 0.05); The serum IGF-1in type 2 diabetic macroangiopathy was obviously lower than thatin type 2 diabetes without complications(P< 0.05); The CIMT in type 2 diabetic macroangiopathy patients was significantly increased than that in healthy controls and type 2 diabetes without complications(P< 0.05);ConclusionsIGF-1 and CIMTis closely correlated with type 2 Diabetic Macroangiopathy，.key words:Diabetes; Macroangiopathy; Insulin-like growth fac...