牡丹籽油软胶囊的质量研究摘 要：目的：优选牡丹籽油软胶囊的制备配方与工艺。方法：用正交试验法考察明胶 AB 比例和甘油配比，以性状、颜色、装量差异以及崩解时限为质量检验项目，筛选出最优的处方工艺。结果：胶皮最佳配比是明胶：甘油：水为 1:0.4:1，明胶 A（203 Bloom g）：明胶 B（120 Bloom g）=3：1；软胶囊的干燥温度是 25℃，冷却定型时间 0.75h，烘干 8～12h。产品性状统一，装量差异偏差不超过 7.5%，崩解时间低于 30min。结论：此工艺稳定可靠，产品质量优异，适于大量生产。关键词：牡丹籽油软胶囊；正交试验法；最优处方工艺；质量检验Abstract ： OBJECTIVE: To optimize the preparation technology of peony seed oil soft capsules. METHODS: The optimum preparation process was selected through the selection of capsule formulation, properties, loading difference and disintegration time. RESULTS: The optimum formulation of rubber skin was gelatin: glycerin: water 1:0.4:1, gelatin A (203 Bloom g): gelatin B (120 Bloom g) = 3:1, The drying temperature of soft capsules is 25 degrees Celsius, the cooling time is 0.75 h, and the drying time is 8-12 H. The test error of three batches of products is less than 4%, and the quality test results of the samples meet the standards. CONCLUSION: The process is stable and reliable, and the quality of the soft capsules is stable. It can be used in large-scale production.Key words：Peony Seed Oil Soft Capsule；Orthogonal experimental design；Optimum preparation process；Sample inspection1 引言 21 世纪以来，各个国家的保健食品发展速度十分迅速。并且多数保健食品均会选择使用软胶囊作为载体。但是研究软胶囊的过程时，胶皮的配方对其质量和性状起到了决定性的作用。配方的优劣，会改变软胶囊的外观、溶出度以及崩解时限。劣质的配方会使其不能符合药典规定标准，还会影响药物发挥疗效，更有甚者会伤害食用者[1]。所以此研究实验用正交试验法考察明胶 AB 比例和甘油配比，以性状、颜色、装量差异以及崩解时限为质量检验项目，筛选出最优的处方工艺。1.1...
