CanineMammaryCanineMammaryTumorsTumors犬的乳腺肿瘤犬的乳腺肿瘤GillianDankGillianDankIntroductionIntroduction绪论绪论Themostcommontumoroffemaledogs(52%)Themostcommontumoroffemaledogs(52%)是母犬最常见的肿瘤是母犬最常见的肿瘤Frequencyofmalignancy-50%Frequencyofmalignancy-50%恶性肿瘤的比率占恶性肿瘤的比率占50%50%EarlydetectionandsmalltumorsizeareimportantprognosticEarlydetectionandsmalltumorsizeareimportantprognosticfactorsforsurvival.factorsforsurvival.早期检测和肿瘤的大小是其存活率的重要预后因素早期检测和肿瘤的大小是其存活率的重要预后因素LocalcontrolwithsurgicalexcisionissuccessfulinprovidingLocalcontrolwithsurgicalexcisionissuccessfulinprovidinglongtermcontrolinamajorityofcases,howeversomelongtermcontrolinamajorityofcases,howeversomepatientswillrequireadjuvantchemotherapypatientswillrequireadjuvantchemotherapy在大部分病例局部的手术切除就可成功的将其长期控制，但有些患畜仍在大部分病例局部的手术切除就可成功的将其长期控制，但有些患畜仍要辅助性化疗要辅助性化疗MorethanhalfofthepatientshavemultiplenodulesattheMorethanhalfofthepatientshavemultiplenodulesatthetimeofdiagnosistimeofdiagnosis诊断时会发现大部分的患畜会长多发结节诊断时会发现大部分的患畜会长多发结节RiskFactorsRiskFactors危险因素危险因素GeneticpredispositionGeneticpredisposition遗传易感性遗传易感性DietDiet饮食饮食–Inonestudy,theriskofdevelopmentofmalignantInonestudy,theriskofdevelopmentofmalignantmammarycancerinspayeddogswasreducedifthemammarycancerinspayeddogswasreducedifthedogswereofleanbodycompositionat9–12monthsofdogswereofleanbodycompositionat9–12monthsofage.age.一项研究表明，如绝育犬在一项研究表明，如绝育犬在9-129-12月大时较瘦，则其患恶性乳月大时较瘦，则其患恶性乳腺癌的危险性就小。腺癌的危险性就小。–ThisfindingwassupportedbyasecondstudyThisfindingwassupportedbyasecondstudyindicatedthatdogsthatwereobeseat1yearofageindicatedthatdogsthatwereobeseat1yearofagehadincreasedriskofdevelopmentofbothbenignandhadincreasedriskofdevelopmentofbothbenignandmalignantmammarytumors.malignantmammarytumors.另一项研究证实了这一说法，即另一项研究证实了这一说法，即11岁时肥胖的犬患良性和恶性岁时肥胖的犬患良性和恶性乳腺肿瘤的危险性会增加。乳腺肿瘤的危险性会增加。RiskFactors-BreedsRiskFactors-Breeds危险因素危险因素——品种品种Suggestsageneticcomponent-notyetidentifiedSuggestsageneticcomponent-notyetidentified建议遗传分组建议遗传分组——尚不能识别尚不能识别–toyandminiaturepoodlestoyandminiaturepoodles玩具和迷你贵宾犬玩具和迷你贵宾犬–englishspringerspanielsenglishspringerspaniels英国史宾格犬英国史宾格犬–britannyspanielsbritannyspaniels–cockerspanielscockerspaniels可卡犬可卡犬–englishsettersenglishsetters英国雪达犬英国雪达犬–PointersPointers波音达犬波音达犬–germanshepherdsgermanshepherds德国牧羊犬德国牧羊犬–MalteseMaltese马尔他犬马尔他犬–yorkshireterriersyorkshireterriers约克夏梗约克夏梗–DachshundsDachshunds腊肠犬腊肠犬MammaryTumours:RiskFactors乳腺肿瘤的危险因素Sex性别Ovariohysterectomy绝育手术AgeatOvariohysterectomy绝育年龄ExogenousProgestogens外源性性激素RiskFactors-OVHRiskFactors-OVH危险因素危险因素——Riskofdevelopmentifspayedpriortothefirstestrusis0.05%;Riskofdevelopmentifspayedpriortothefirstestrusis0.05%;8%afterthefirstestrus,and26%ifspayedafterthesecond8%afterthefirstestrus,and26%ifspayedafterthesecondestrusascomparedtotheriskinintactfemales.estrusascomparedtotheriskinintactfemales.第一次发情前绝育（摘...
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