中国中医科学院西苑医院心血管中心史大卓ShiDazhuoXiyuanHospital,ChinaAcademyofChineseMedicalsciences补充替代医学与现代医学ComplementaryandAlternativeMedicine&WesternMedicine一.现代医学的迅速发展DevelopmentofContemporarymedicine二.传统中医学的优势SuperioritiesofTCM三.传统中医药学对现代医学发展的启示TheilluminationforcontemporarymedicaldevelopmentVariousinterventionsfordiseasesincludingmodernmechanicalmeasurementsandnewdrugsbringnewhopeforpreventionandtreatment.However,lookingatthewholepictureofmodernmedicinewefindthatwhatwecandoisstillverylimited.现代各种干预疾病的机械措施和新药物,为疾病预防和治疗带来了新的希望,但环顾现代疾病谱的整个画面,发现我们能够做的还非常局限。中国糖尿病人数超过印度不要说肿瘤、AIDS、糖尿病,即使普通病毒性感冒,西药也是对症治疗,对病理过程基本无作用。Don’tmentioncancer,AIDS,diabetes,eventhoughthecommonviralinfluenza,thewesternmedicinehasnoobviouseffectonthepathologicalprocess.1.冠心病(Coronaryheartdisease)血运重建治疗(RevascularizationTreatments)新药物和新技术不断出现,并应用于临床,尤其是抗血小板和调节脂质代谢方面基因治疗、干细胞移植、生物支架技术的应用,显示有良好的应用前景Genetherapy,stemcelltransplantationandbiologicalstentshowagoodprospect.Newdrugsandnewtechnologies,especiallyantiplateletandregulationoflipidmetabolismareemergingandapplyinginclinicalpractice.炎症反应(inflammationreaction)氧化应激损伤(oxidativestress)内皮功能障碍(endothelialdysfunction)抗药性(Drugresistance)无复流慢复流(noreflow&slowreflow)再灌注损伤(ischemia-reperfusioninjury)冠脉内血栓(thrombusformationincoronaryartery)远期血管狭窄(longtermvascularstenosis)(interventionaltherapy)(conventionaltreatmentofwesternmedicine)缺乏理想干预手段,成为影响长期预后的瓶颈(Nogoodtreatments&bottleneckoflong-termprognosis)LimSY,etal.CircJ.2004;68(10):928-932存在问题(Problems)介入治疗西药常规冠心病(CHD)发病率和死亡率不断增加发病率和死亡率不断增加(Incidenceandmortalityincreasedconstantly)(Incidenceandmortalityincreasedconstantly)发病年龄年轻化发病年龄年轻化(Incidencebecomemuchyounger)(Incidencebecomemuchyounger)公共卫生的首要重大疾病之一公共卫生的首要重大疾病之一((OneofthemostmajordiseasesofpublichealthOneofthemostmajordiseasesofpublichealth))心脏病中住院人数第一largestnumberininpaiteintswithheartdisease住院疾病平均费用第一Firstaveragecostforinpatients在心脏病中死亡率第一Firstmortalityofheartdisease心脏病院外死亡比例第一FirstmortalityinoutsidethehospitalsACS介入治疗后1年心脏事件的发生率18%(Theincidenceofcardiaceventsafter1yearinterventionwas18%.)(NEnglJMed2006;355(1):1093)心血管病致残和死亡主要原因(leadingcauseofcardiovasculardisabilityanddeath)介入治疗和药物涂层支架(InterventionaltherapyandDES)不稳定心绞痛(Unstableangina)非ST段抬高心梗(NSTEMI)ST段抬高心梗(STEMI)2.慢性心衰(Chronicheartfailure)5年的死亡率达到67%左右(5-yearmortalityratewas67%)NEnglJMed2010;362:228-383.心律失常(Arrhythmia)抗心律失常药,除β受体阻滞剂外的病因治疗外,直接抑制心律失常的药物对长期预后皆有负面作用。心律失常目前基本是病因治疗、对症治疗、介入治疗Antiarrhythmicdrugs,excepttheβ-blocker,drugsfordirectinhibitionofarrhythmiahavenegativeeffectsonlong-termprognosis.Thecurrenttreatmentofarrhythmiaisetiological,symptomatictreatmentandinterventiontherapy4.恶性肿瘤(malignancy)手术、化疗、放疗(operation,chemotherapy,radiotherapy)肿瘤血管靶向治疗(tumorvasculartargetingtherapy)生物疗法(biotherapy)介入治疗(interventio...